AKCCHF grant #00366

Update: This research study is complete. Samples are no longer required.

Molecular Control of COX-2 Expression and Regulation of Prostaglandin Transport in Canine Mammary Tumors

Monique Dore, DVM PhD, University of Montreal.

Mammary Cancer Research to benefit dogs and humans! This is an extension of the previous study (AKCCHF#02222) on the connection between elevated levels of the COX-2 enzyme and the development of mammary tumors. So far, Doré’s research has shown “that COX-2 was not expressed in the normal (mammary) gland but was detected in 24% of adenomas and in 56% of adenocarcinomas (P < 0.001).”


Samoyed Club of America Education & Research Foundation, Inc.


Dr. Monique Doré, DVM, MSc, PhD, Dipl. ACVP

Université de Montréal

I thank you very much for your precious help with this research.“ from Monique Doré, DVM, MSc, PhD, Dipl. ACVP

Abstract from the AKCCHF.org website:

“Tumors originating from the mammary gland represent one of the most frequent forms of cancer in female dogs. However, very little information is known about the mechanisms involved in the development of this cancer. In dogs, the growth of mammary tumors can recur following surgical excision or cancerous cells can appear in distant organs. Cyclooxygenase-2 (COX-2), an enzyme that is essential in the production of prostaglandins, has been implicated in various forms of cancer in humans, including breast cancer. We have recently reported for the first time that COX-2 is induced in the majority of canine malignant mammary tumors. The objective of this proposal is to study the molecular mechanisms involved in the regulation of COX-2 gene expression in canine mammary tumors. We will also characterize the expression of a novel prostaglandin transporter in these tumors. It is expected that a better comprehension of the mechanisms involved in COX-2 expression and prostaglandin transport in canine mammary cancer will help design new strategies for cancer therapy and prevention in dogs.”

Read all about this exciting research in Dr. Doré’s publications that were supported by AKCCHF grants #02222 and #00366:

Dore M et al. Cyclooxygenase-2 Expression in Canine Mammary Tumors. 2003. Veterinary Pathology 40: 207-212.

Brunell M, Sartin EA, Wolfe LG, Sirois J & Dore M. Cyclooxygenase-2 Expression in Normal and Neoplastic Canine Mammary Cell Lines. 2006. Veterinary Pathology 43:656-666.

Dore M. Cyclooxygenase-2 Expression in Animal Cancers. 2011. Veterinary Pathology 48:254-265.