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Immune-Mediated Thrombocytopenia

Liaison: Patti Emmett, MS, RN, CIC
Email: sunfiresams@bigfoot.com

Decreased numbers of blood platelets due to platelet destruction by the immune system.


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Signs and Symptoms

Spontaneous visible bruising is the major clinical sign.  Small spidery spots of bruising clustered together are called "petechiae".  Petechiae are the most common sign.  Larger purple areas of bruising are called "ecchymosis". 


Causes

In many cases, a cause isn't found.  In some cases, a primary reaction by the immune system precedes the act of platelet destruction. 

 

Examples of reactions in the immune system that could be followed by platelet destruction include:

  • a parasitic infection of blood (Ehrlichiosis, Rocky Mountain Spotted Fever)
  • a tumor
  • drugs (chemotherapy agents, sulfonamide and chloramphenicol antibiotics)
  • Lupus

Risk Factors

  • exposure to ticks and tick-borne blood parasites
  • pre-existing Lupus
  • a diagnosis of bone marrow cancer
  • certain treatments for cancer and infections

Diagnostic Tests

Inspection of gums and mouth, whites of the eyes, and abdomen may reveal petechiae or ecchymosis.  Blood platelet counts can determine if numbers of platelets are normal or too low, or appear abnormal.  Tests are not yet available to detect anti-platelet antibodies.  Veterinarian diagnosis on a case-by-case basis, using tests for other diseases combined with symptom assessment.


Treatment Guidelines

Note: Treatment of animals should only be performed by a licensed veterinarian. Veterinarians should consult the current literature and current pharmacological formularies before initiating any treatment protocol.

  • Treatment of the cause, if known
  • Prednisone or dexamethasone immunosuppression
  • Azathioprine if no response to above
  • Transfusion when a crisis occurs
  • Splenectomy

References

  1. Barlough,J.E., Pedersen, N.C, 1995. "The immune system and disorders" in UC Davis School of Vet Med book of dogs.  Siegal, M. Ed., p.331-333. Harper Collins, New York. three bones rating
  2. Williams,D.A., Maggio-Price, L., 1984. Canine idiopathic thrombocytopenia: clinical observations and long-term follow-up in 54 cases. J Am Vet Med Assoc 15; 185(6):p.660-663. Link to abstract  four bones rating
  3. Kohn, B., 2003.  Immune-mediated thrombocytopenia – current approach. 28th World Congress of World Small Animal Veterinary Assoc, Thailand p.1-3.  four bones rating
  4. Trepanier, L.A., Danhof, R., Toll, J., and Watrous, D.  Clinical findings in 40 dogs with hypersensitivity associated with administration of potentiated sulfonamides.  J Vet Int Med  9; 2003 Sep-Oct; 17(5):p. 647-652. Link to abstract  four bones rating

 




 

 
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