Sponsored research studies that have been completed.
Completed Grant #1637:
Identification of DNA Marker(s) for Cataracts in Purebred Dogs, with Emphasis on the Breeds Alaskan Malamute, Siberian Husky, and Samoyed
The CHF funded Dr. Vilma Yuzbasiyan-Gurkan, Dr. David Ramsey and Dr. Simon Petersen-Jones at Michigan State University to do a study entitled: Identification of DNA Marker(s) for Cataracts in Purebred Dogs, with Emphasis on the Breeds Alaskan Malamute, Siberian Husky and Samoyed in 1998. This study was completed in late 2001. The objectives were to collect DNA, clinical information and pedigrees from representatives of the three target breeds and then to evaluate mode of inheritance and penetrance by age and clinical outcome. They planned to evaluate linkage of microsatellite markers distributed throughout the canine genome. If linked markers could be identified they would map them on the available reference pedigrees. They hoped to be able to evaluate candidate genes by sequencing the DNA of the parallel canine gene.
Their results support an autosomal recessive mode of inheritance in all three breeds. Their data supports a ‘founder effect’ for cataracts in each breed. They believe that they were able to identify one marker that is associated with juvenile cataracts in one extensive Samoyed pedigree. Further studies that the group was able to perform did not allow identification of any specific gene as the likely candidate for cataracts in our breed.
Completed Grant # 1836:
Identifying the Genetic Cause of Canine Hip Dysplasia
This study was completed at the end of 2003. Their objectives were to evaluate 13 candidate genes as causal for canine hip dysplasia (CHD). All of the selected genes were analyzed, but no linkage was found to CHD in any of the breeds studied. Samoyed samples were included in this study.
Completed Grant No: 2222:
Molecular Control of Prostaglandin Synthesis in Canine Mammary
So far, Dr. Doré's research has shown "that COX-2 was not expressed in the normal (mammary) gland but was detected in 24% of adenomas and in 56% of adenocarcinomas (P < 0.001). " Read all about this exciting research HERE. Dr. Doré is continuing her research with AKCCHF grant #0366.
Completed Grant No: 2277:
Identification of the Genetic Cause or Causes for Cataracts in Several Breeds
Thirty-one cataract genes in four breeds (Cockers, Goldens, Labs and Poodles) were tested. However, there were no linkages found.