Document Actions
Research Articles
There appears to be no current research, however the following papers are indicated in a synopsis of the disease on http://www.addl.purdue.edu/newsletters/2004/spring/tremors.htm
- Bagley RS: 1992. Tremor syndromes in dogs: Diagnosis and treatment. J Small An Med 33: 485-589. (unable to rate)
- Bagley RS, Kornegay J, Wheeler S, et al: 1993. Generalized Tremor in Maltese: clinical findings in seven cases. JAAHA 29: 141-145.
- Cuddon P:1990. Tremor syndromes. Progress in Veterinary Neurology. 1:285-298. (unable to rate)
- Ettinger and Feldman: 2000. Textbook of Veterinary Internal Medicine. WB Saunders, Philadelphia.
- Wagner S, Podell M and Fenner WR: 1997. Generalized tremors in dogs: 24 cases. JAVMA 211(6): 731-735.
There is research being done on tremors in Samoyeds caused by hypomyelination. These tremors are seen in very young (several weeks old) puppies. If you think you have seen this condition, you may be able to assist in this research. Please feel free to contact Dr. Ian Duncan by email or phone (608-265-1129). The condition is described in the following paper:
Cummings JF, Summers BA, de Lahunta A, Lawson C. Acta Neuropathol (Berl). 1986;71(3-4):267-77. Tremors in Samoyed pups with oligodendrocyte deficiencies and hypomyelination. 
Abstract:
Over a 3-year period a breeder of Samoyed dogs observed six litters in which one or more pups at 3 weeks of age showed generalized tremors and an inability to stand. One affected pup, a 5-week-old male, was referred for clinical and pathological evaluation. Gross and microscopic studies including immunocytochemical demonstration of myelin basic protein, revealed a lack of myelin throughout the central nervous system. Ultrastructural studies revealed that a total absence of normal myelin was associated with oligodendroglial deficiencies. Oligodendrocytes were immature in appearance, greatly reduced in number, and incapable of forming compact myelin. Astrocytosis and an increase in the third type of neuroglial cells were observed. The changes differed from those reported in other canine forms of hypomyelinogenesis and were compared with hypomyelinating diseases in other species. The findings suggested that this hypomyelination was the result of retarded gliogenesis.
